A novel LysR‐type regulator negatively affects biosynthesis of the immunosuppressant brasilicardin

Brasilicardin A (BraA) is a promising immunosuppressive compound produced naturally by the pathogenic bacterium Nocardia terpenica IFM 0406. Heterologous host expression of brasilicardin gene cluster showed to be efficient to bypass the safety issues, low production levels and lack of genetic tools...

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Detalhes bibliográficos
Publicado no:Eng Life Sci
Main Authors: Wolański, Marcin, Krawiec, Michał, Schwarz, Paul N., Stegmann, Evi, Wohlleben, Wolfgang, Buchmann, Anina, Gross, Harald, Eitel, Michael, Koch, Pierre, Botas, Alma, Méndez, Carmen, Núñez, Luz Elena, Morís, Francisco, Cortés, Jesus, Zakrzewska‐Czerwińska, Jolanta
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7837296/
https://ncbi.nlm.nih.gov/pubmed/33531886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/elsc.202000038
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