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Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle

Hypertrophic cardiomyopathy (HCM) is frequently linked to mutations in the protein components of the myosin-containing thick filaments leading to contractile dysfunction and ultimately heart failure. However, the molecular structure-function relationships that underlie these pathological effects rem...

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Bibliografski detalji
Izdano u:J Mol Cell Cardiol
Glavni autori: Kampourakis, Thomas, Ponnam, Saraswathi, Irving, Malcolm
Format: Artigo
Jezik:Inglês
Izdano: Academic Press 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5883317/
https://ncbi.nlm.nih.gov/pubmed/29452157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.02.009
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