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Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle
Hypertrophic cardiomyopathy (HCM) is frequently linked to mutations in the protein components of the myosin-containing thick filaments leading to contractile dysfunction and ultimately heart failure. However, the molecular structure-function relationships that underlie these pathological effects rem...
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| Published in: | J Mol Cell Cardiol |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Academic Press
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5883317/ https://ncbi.nlm.nih.gov/pubmed/29452157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.02.009 |
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