Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I

Heart muscle contractility and performance are controlled by posttranslational modifications of sarcomeric proteins. Although myosin regulatory light chain (RLC) phosphorylation has been studied extensively in vitro and in vivo, the precise role of cardiac myosin light chain kinase (cMLCK), the prim...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Sevrieva, Ivanka R., Brandmeier, Birgit, Ponnam, Saraswathi, Gautel, Mathias, Irving, Malcolm, Campbell, Kenneth S., Sun, Yin-Biao, Kampourakis, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7135997/
https://ncbi.nlm.nih.gov/pubmed/32086378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011945
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