Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I

Heart muscle contractility and performance are controlled by posttranslational modifications of sarcomeric proteins. Although myosin regulatory light chain (RLC) phosphorylation has been studied extensively in vitro and in vivo, the precise role of cardiac myosin light chain kinase (cMLCK), the prim...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sevrieva, Ivanka R., Brandmeier, Birgit, Ponnam, Saraswathi, Gautel, Mathias, Irving, Malcolm, Campbell, Kenneth S., Sun, Yin-Biao, Kampourakis, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7135997/
https://ncbi.nlm.nih.gov/pubmed/32086378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011945
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