Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT

Mastocytosis is a disorder resulting from an abnormal mast cell (MC) accumulation in tissues that is often associated with the D816V mutation in KIT, the tyrosine kinase receptor for stem cell factor. Therapies available to treat aggressive presentations of mastocytosis are limited, thus exploration...

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Detaylı Bibliyografya
Yayımlandı:Front Immunol
Asıl Yazarlar: Bandara, Geethani, Muñoz-Cano, Rosa, Tobío, Araceli, Yin, Yuzhi, Komarow, Hirsh D., Desai, Avanti, Metcalfe, Dean D., Olivera, Ana
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2018
Konular:
Immunology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5883065/
https://ncbi.nlm.nih.gov/pubmed/29643855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00631
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