Targeting the KIT Activating Switch Control Pocket: A Novel Mechanism to Inhibit Neoplastic Mast Cell Proliferation and Mast Cell Activation

Activating mutations in the receptor tyrosine kinase KIT, most notably KIT D816V, are commonly observed in patients with systemic mastocytosis. Thus, inhibition of KIT has been a major focus for treatment of this disorder. Here we investigated a novel approach to such inhibition. Utilizing rational...

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Autori principali: Bai, Yun, Bandara, Geethani, Chan, Eunice Ching, Maric, Irina, Simakova, Olga, Bandara, Sachini N., Lu, Wei-Ping, Wise, Scott C., Flynn, Daniel L., Metcalfe, Dean D., Gilfillan, Alasdair M., Wilson, Todd M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529859/
https://ncbi.nlm.nih.gov/pubmed/22907049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.218
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