Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT

Mastocytosis is a disorder resulting from an abnormal mast cell (MC) accumulation in tissues that is often associated with the D816V mutation in KIT, the tyrosine kinase receptor for stem cell factor. Therapies available to treat aggressive presentations of mastocytosis are limited, thus exploration...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Bandara, Geethani, Muñoz-Cano, Rosa, Tobío, Araceli, Yin, Yuzhi, Komarow, Hirsh D., Desai, Avanti, Metcalfe, Dean D., Olivera, Ana
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5883065/
https://ncbi.nlm.nih.gov/pubmed/29643855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00631
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