Selective mTORC2 inhibitor therapeutically blocks breast cancer cell growth and survival

Small molecule inhibitors of the mTORC2 kinase (torkinibs) have shown efficacy in early clinical trials. However, the torkinibs under study also inhibit the other mTOR-containing complex mTORC1. While mTORC1/mTORC2 combined inhibition may be beneficial in cancer cells, recent reports describe compen...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Werfel, Thomas A., Wang, Shan, Jackson, Meredith A., Kavanaugh, Taylor E., Joly, Meghan Morrison, Lee, Linus H., Hicks, Donna J., Sanchez, Violeta, Ericsson, Paula Gonzalez, Kilchrist, Kameron V., Dimobi, Somtochukwu C., Sarett, Samantha M., Brantley-Sieders, Dana, Cook, Rebecca S., Duvall, Craig L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882532/
https://ncbi.nlm.nih.gov/pubmed/29358172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2388
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