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Thrombin Stimulates Increased PAI-1 Release from Liver Compared to Lung Endothelium

BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) is a major regulator of the fibrinolytic system, covalently binding to tissue plasminogen activator (tPA) and blocking its activity. Fibrinolysis shutdown is evident in the majority of severely injured patients in the first 24 hours and is though...

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Detalhes bibliográficos
Publicado no:J Surg Res
Main Authors: Huebner, Benjamin R, Moore, Ernest E, Moore, Hunter B, Gonzalez, Eduardo, Kelher, Marguerite R, Sauaia, Angela, Banerjee, Anirban, Silliman, Christopher C
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881926/
https://ncbi.nlm.nih.gov/pubmed/29605018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2017.12.017
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