Overwhelming tPA Release, not PAI-1 Degradation, is Responsible for Hyperfibrinolysis in Severely Injured Trauma Patients

BACKGROUND: Trauma induced coagulopathy (TIC) is associated with a four-fold increased risk of mortality. Hyperfibrinolysis is a component of TIC, but its mechanism is poorly understood. PAI-1 degradation by activated protein C has been proposed as mechanism for deregulation of the plasmin system in...

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Xehetasun bibliografikoak
Argitaratua izan da:J Trauma Acute Care Surg
Egile Nagusiak: Chapman, Michael P., Moore, Ernest E., Moore, Hunter B., Gonzalez, Eduardo, Gamboni, Fabia, Chandler, James G., Mitra, Sanchayita, Ghasabyan, Arsen, Chin, Theresa L., Sauaia, Angela, Banerjee, Anirban, Silliman, Christopher C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688194/
https://ncbi.nlm.nih.gov/pubmed/26491796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000000885
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