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Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient

Postinjury fibrinolysis can manifest as three distinguishable phenotypes: 1) hyperfibrinolysis, 2) physiologic, and 3) hypofibrinolysis (shutdown). Hyperfibrinolysis is associated with uncontrolled bleeding due to clot dissolution; whereas, fibrinolysis shutdown is associated with organ dysfunction...

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Detalhes bibliográficos
Publicado no:Transfusion
Main Authors: Moore, Ernest E., Moore, Hunter B., Gonzalez, Eduardo, Sauaia, Angela, Banerjee, Anirban, Silliman, Christopher C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688850/
https://ncbi.nlm.nih.gov/pubmed/27100746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/trf.13486
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