A small‐molecule PAI‐1 inhibitor prevents bone loss by stimulating bone formation in a murine estrogen deficiency‐induced osteoporosis model

Osteoporosis is a progressive bone disease caused by an imbalance between bone resorption and formation. Recently, plasminogen activator inhibitor‐1 (PAI‐1) was shown to play an important role in bone metabolism using PAI‐1‐deficient mice. In this study, we evaluated the therapeutic benefits of nove...

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Enregistré dans:
Détails bibliographiques
Publié dans:FEBS Open Bio
Auteurs principaux: Jin, Guangwen, Aobulikasimu, Alkebaier, Piao, Jinying, Aibibula, Zulipiya, Koga, Daisuke, Sato, Shingo, Ochi, Hiroki, Tsuji, Kunikazu, Nakabayashi, Tetsuo, Miyata, Toshio, Okawa, Atsushi, Asou, Yoshinori
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881535/
https://ncbi.nlm.nih.gov/pubmed/29632806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12390
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