Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling

Sirtuin 6 (Sirt6) is a mammalian homologue of NAD(+)-dependent histone deacetylase Sir2. Although Sirt6−/− mice exhibit growth retardation, the role of Sirt6 in cartilage metabolism is unclear. The aim of this study was to investigate the Sirt6 signaling pathway in cartilage metabolism. Immunohistol...

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Vydáno v:Sci Rep
Hlavní autoři: Piao, Jinying, Tsuji, Kunikazu, Ochi, Hiroki, Iwata, Munetaka, Koga, Daisuke, Okawa, Atsushi, Morita, Sadao, Takeda, Shu, Asou, Yoshinori
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505680/
https://ncbi.nlm.nih.gov/pubmed/24149372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03022
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