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Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling
Sirtuin 6 (Sirt6) is a mammalian homologue of NAD(+)-dependent histone deacetylase Sir2. Although Sirt6−/− mice exhibit growth retardation, the role of Sirt6 in cartilage metabolism is unclear. The aim of this study was to investigate the Sirt6 signaling pathway in cartilage metabolism. Immunohistol...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6505680/ https://ncbi.nlm.nih.gov/pubmed/24149372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03022 |
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