A small‐molecule PAI‐1 inhibitor prevents bone loss by stimulating bone formation in a murine estrogen deficiency‐induced osteoporosis model

Osteoporosis is a progressive bone disease caused by an imbalance between bone resorption and formation. Recently, plasminogen activator inhibitor‐1 (PAI‐1) was shown to play an important role in bone metabolism using PAI‐1‐deficient mice. In this study, we evaluated the therapeutic benefits of nove...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Jin, Guangwen, Aobulikasimu, Alkebaier, Piao, Jinying, Aibibula, Zulipiya, Koga, Daisuke, Sato, Shingo, Ochi, Hiroki, Tsuji, Kunikazu, Nakabayashi, Tetsuo, Miyata, Toshio, Okawa, Atsushi, Asou, Yoshinori
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881535/
https://ncbi.nlm.nih.gov/pubmed/29632806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12390
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