Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells

Schwann cells respond to cyclic adenosine monophosphate (cAMP) halting proliferation and expressing myelin proteins. Here we show that cAMP signaling induces the nuclear shuttling of the class IIa histone deacetylase (HDAC)–4 in these cells, where it binds to the promoter and blocks the expression o...

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Publicat a:J Cell Biol
Autors principals: Gomis-Coloma, Clara, Velasco-Aviles, Sergio, Gomez-Sanchez, Jose A., Casillas-Bajo, Angeles, Backs, Johannes, Cabedo, Hugo
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2018
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Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881490/
https://ncbi.nlm.nih.gov/pubmed/29472387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201611150
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