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MARCH1 protects the lipid raft and tetraspanin web from MHCII proteotoxicity in dendritic cells

Dendritic cells (DCs) produce major histocompatibility complex II (MHCII) in large amounts to function as professional antigen presenting cells. Paradoxically, DCs also ubiquitinate and degrade MHCII in a constitutive manner. Mice deficient in the MHCII-ubiquitinating enzyme membrane-anchored RING-C...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Oh, Jaehak, Perry, Justin S.A., Pua, Heather, Irgens-Möller, Nicole, Ishido, Satoshi, Hsieh, Chyi-Song, Shin, Jeoung-Sook
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881489/
https://ncbi.nlm.nih.gov/pubmed/29371232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201611141
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