MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells

Membrane-associated RING-CH1 (MARCH1) is an E3 ubiquitin ligase that mediates ubiquitination of MHCII in dendritic cells (DCs). MARCH1-mediated MHCII ubiquitination in DCs is known to regulate MHCII surface expression, thereby controlling DC-mediated T cell activation in vitro. However, its role at...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Oh, Jaehak, Wu, Nan, Baravalle, Günther, Cohn, Benjamin, Ma, Jessica, Lo, Bryan, Mellman, Ira, Ishido, Satoshi, Anderson, Mark, Shin, Jeoung-Sook
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2013
Schlagworte:
Brief Definitive Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674695/
https://ncbi.nlm.nih.gov/pubmed/23712430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122695
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