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MARCH1 protects the lipid raft and tetraspanin web from MHCII proteotoxicity in dendritic cells
Dendritic cells (DCs) produce major histocompatibility complex II (MHCII) in large amounts to function as professional antigen presenting cells. Paradoxically, DCs also ubiquitinate and degrade MHCII in a constitutive manner. Mice deficient in the MHCII-ubiquitinating enzyme membrane-anchored RING-C...
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| Veröffentlicht in: | J Cell Biol |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Rockefeller University Press
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5881489/ https://ncbi.nlm.nih.gov/pubmed/29371232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201611141 |
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