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TAK1ng control: TAK1 restrains NLRP3 activation
In this issue of JEM, Malireddi et al. (https://doi.org/10.1084/jem.20171922) demonstrate that macrophage-specific loss of TAK1 causes spontaneous NLRP3 inflammasome activation, driven by unregulated TNF secretion and signaling. This has implications for therapeutically targeting TAK1, enhancing its...
Tallennettuna:
| Julkaisussa: | J Exp Med |
|---|---|
| Päätekijät: | , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Rockefeller University Press
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5881475/ https://ncbi.nlm.nih.gov/pubmed/29507056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180282 |
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