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TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

The NOD-like receptor (NLR)–P3 inflammasome is a global sensor of infection and stress. Elevated NLRP3 activation levels are associated with human diseases, but the mechanisms controlling NLRP3 inflammasome activation are largely unknown. Here, we show that TGF-β activated kinase-1 (TAK1) is a centr...

詳細記述

保存先:
書誌詳細
出版年:J Exp Med
主要な著者: Malireddi, R.K. Subbarao, Gurung, Prajwal, Mavuluri, Jayadev, Dasari, Tejasvi Krishna, Klco, Jeffery M., Chi, Hongbo, Kanneganti, Thirumala-Devi
フォーマット: Artigo
言語:Inglês
出版事項: Rockefeller University Press 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881469/
https://ncbi.nlm.nih.gov/pubmed/29500178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171922
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