TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

The NOD-like receptor (NLR)–P3 inflammasome is a global sensor of infection and stress. Elevated NLRP3 activation levels are associated with human diseases, but the mechanisms controlling NLRP3 inflammasome activation are largely unknown. Here, we show that TGF-β activated kinase-1 (TAK1) is a centr...

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Publicat a:J Exp Med
Autors principals: Malireddi, R.K. Subbarao, Gurung, Prajwal, Mavuluri, Jayadev, Dasari, Tejasvi Krishna, Klco, Jeffery M., Chi, Hongbo, Kanneganti, Thirumala-Devi
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881469/
https://ncbi.nlm.nih.gov/pubmed/29500178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171922
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