Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner

BACKGROUND: Magnetic resonance spectroscopy (MRS) studies have identified elevated levels of the phospholipid precursor phosphocholine (PC) and phosphoethanolamine (PE) as metabolic hallmarks of cancer. Unusually, however, PC and PE levels are reduced in mutant isocitrate dehydrogenase 1 (IDHmut) gl...

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Publicat a:Cancer Metab
Autors principals: Viswanath, Pavithra, Radoul, Marina, Izquierdo-Garcia, Jose Luis, Luchman, Hema Artee, Gregory Cairncross, J., Pieper, Russell O., Phillips, Joanna J., Ronen, Sabrina M.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881177/
https://ncbi.nlm.nih.gov/pubmed/29619216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-018-0178-3
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