Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner

BACKGROUND: Magnetic resonance spectroscopy (MRS) studies have identified elevated levels of the phospholipid precursor phosphocholine (PC) and phosphoethanolamine (PE) as metabolic hallmarks of cancer. Unusually, however, PC and PE levels are reduced in mutant isocitrate dehydrogenase 1 (IDHmut) gl...

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Detalhes bibliográficos
Publicado no:Cancer Metab
Main Authors: Viswanath, Pavithra, Radoul, Marina, Izquierdo-Garcia, Jose Luis, Luchman, Hema Artee, Gregory Cairncross, J., Pieper, Russell O., Phillips, Joanna J., Ronen, Sabrina M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881177/
https://ncbi.nlm.nih.gov/pubmed/29619216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-018-0178-3
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