Sumoylation Protects Against β-Synuclein Toxicity in Yeast

Aggregation of α-synuclein (αSyn) plays a central role in the pathogenesis of Parkinson’s disease (PD). The budding yeast Saccharomyces cerevisiae serves as reference cell to study the interplay between αSyn misfolding, cytotoxicity and post-translational modifications (PTMs). The synuclein family i...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Popova, Blagovesta, Kleinknecht, Alexandra, Arendarski, Patricia, Mischke, Jasmin, Wang, Dan, Braus, Gerhard H.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880895/
https://ncbi.nlm.nih.gov/pubmed/29636661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00094
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