Interplay between Sumoylation and Phosphorylation for Protection against α-Synuclein Inclusions

Parkinson disease is associated with the progressive loss of dopaminergic neurons from the substantia nigra. The pathological hallmark of the disease is the accumulation of intracytoplasmic inclusions known as Lewy bodies that consist mainly of post-translationally modified forms of α-synuclein. Whe...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Shahpasandzadeh, Hedieh, Popova, Blagovesta, Kleinknecht, Alexandra, Fraser, Paul E., Outeiro, Tiago F., Braus, Gerhard H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223324/
https://ncbi.nlm.nih.gov/pubmed/25231978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.559237
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