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Interplay between Sumoylation and Phosphorylation for Protection against α-Synuclein Inclusions

Parkinson disease is associated with the progressive loss of dopaminergic neurons from the substantia nigra. The pathological hallmark of the disease is the accumulation of intracytoplasmic inclusions known as Lewy bodies that consist mainly of post-translationally modified forms of α-synuclein. Whe...

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Foilsithe in:J Biol Chem
Main Authors: Shahpasandzadeh, Hedieh, Popova, Blagovesta, Kleinknecht, Alexandra, Fraser, Paul E., Outeiro, Tiago F., Braus, Gerhard H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223324/
https://ncbi.nlm.nih.gov/pubmed/25231978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.559237
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