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Ferrochelatase π-Helix: Implications from Examining the Role of the Conserved π-Helix Glutamates in Porphyrin Metalation and Product Release

Protoporphyrin ferrochelatase catalyzes the insertion of Fe(2+) into protoporphyrin IX to form heme. To determine whether a conserved, active site π-helix contributes to the translocation of the metal ion substrate to the ferrochelatase-bound porphyrin substrate, the invariant π-helix glutamates wer...

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Bibliografiske detaljer
Udgivet i:Arch Biochem Biophys
Main Authors: Gillam, Mallory E., Hunter, Gregory A., Ferreira, Gloria C.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880697/
https://ncbi.nlm.nih.gov/pubmed/29481781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2018.02.015
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