JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice

BACKGROUND & AIMS: Maintenance of acid–base homeostasis is required for normal physiology, metabolism, and development. It is not clear how cell death is activated in response to changes in pH. We performed a screen to identify agents that induce cell death in a pH-dependent manner (we call this...

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Publicado no:Gastroenterology
Main Authors: Song, Xinxin, Zhu, Shan, Xie, Yangchun, Liu, Jiao, Sun, Lingyi, Zeng, Dexing, Wang, Pengcheng, Ma, Xiaochao, Kroemer, Guido, Bartlett, David L., Billiar, Timothy R., Lotze, Michael, Zeh, Herbert, Kang, Rui, Tang, Daolin
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880694/
https://ncbi.nlm.nih.gov/pubmed/29248440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.12.004
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