Hedgehog–YAP Signaling Pathway Regulates Glutaminolysis to Control Hepatic Stellate Cell Activation

BACKGROUND & AIMS: Cirrhosis results from accumulation of myofibroblasts derived from quiescent hepatic stellate cells (Q-HSCs); it regresses when myofibroblastic HSCs are depleted. Hedgehog signaling promotes transdifferentiation of HSCs by activating Yes-associated protein 1 (YAP1 or YAP) and...

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Pubblicato in:Gastroenterology
Autori principali: Du, Kuo, Hyun, Jeongeun, Premont, Richard T., Choi, Steve S., Michelotti, Gregory A., Swiderska-Syn, Marzena, Dalton, George D., Thelen, Eric, Rizi, Bahar Salimian, Jung, Youngmi, Diehl, Anna Mae
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880682/
https://ncbi.nlm.nih.gov/pubmed/29305935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.12.022
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