Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism

BACKGROUND & AIMS: Pathogenesis of cirrhosis, a disabling outcome of defective liver repair, involves deregulated accumulation of myofibroblasts derived from quiescent hepatic stellate cells (HSC), but the mechanisms that control HSC transdifferentiation are poorly understood. We investigated wh...

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Autori principali: Chen, Yuping, Choi, Steve S., Michelotti, Gregory A., Chan, Isaac S., Swiderska, Marzena, Karaca, Gamze F., Xie, Guanhua, Moylan, Cynthia A., Garibaldi, Francesca, Premont, Richard, Suliman, Hagir B., Piantodosi, Claude A., Diehl, Anna Mae
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480563/
https://ncbi.nlm.nih.gov/pubmed/22885334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2012.07.115
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