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DEC2 modulates orexin expression and regulates sleep

Adequate sleep is essential for physical and mental health. We previously identified a missense mutation in the human DEC2 gene (BHLHE41) leading to the familial natural short sleep behavioral trait. DEC2 is a transcription factor regulating the circadian clock in mammals, although its role in sleep...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hirano, Arisa, Hsu, Pei-Ken, Zhang, Luoying, Xing, Lijuan, McMahon, Thomas, Yamazaki, Maya, Ptáček, Louis J., Fu, Ying-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879715/
https://ncbi.nlm.nih.gov/pubmed/29531056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801693115
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