TIMELESS mutation alters phase responsiveness and causes advanced sleep phase

Many components of the circadian molecular clock are conserved from flies to mammals; however, the role of mammalian Timeless remains ambiguous. Here, we report a mutation in the human TIMELESS (hTIM) gene that causes familial advanced sleep phase (FASP). Tim CRISPR mutant mice exhibit FASP with alt...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kurien, Philip, Hsu, Pei-Ken, Leon, Jacy, Wu, David, McMahon, Thomas, Shi, Guangsen, Xu, Ying, Lipzen, Anna, Pennacchio, Len A., Jones, Christopher R., Fu, Ying-Hui, Ptáček, Louis J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6575169/
https://ncbi.nlm.nih.gov/pubmed/31138685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819110116
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