A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait

In humans, the connection between sleep and mood has long been recognized, although direct molecular evidence is lacking. We identified two rare variants in the circadian clock gene PERIOD3 (PER3-P415A/H417R) in humans with familial advanced sleep phase accompanied by higher Beck Depression Inventor...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Zhang, Luoying, Hirano, Arisa, Hsu, Pei-Ken, Jones, Christopher R., Sakai, Noriaki, Okuro, Masashi, McMahon, Thomas, Yamazaki, Maya, Xu, Ying, Saigoh, Noriko, Saigoh, Kazumasa, Lin, Shu-Ting, Kaasik, Krista, Nishino, Seiji, Ptáček, Louis J., Fu, Ying-Hui
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2016
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PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801303/
https://ncbi.nlm.nih.gov/pubmed/26903630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600039113
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