A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait

In humans, the connection between sleep and mood has long been recognized, although direct molecular evidence is lacking. We identified two rare variants in the circadian clock gene PERIOD3 (PER3-P415A/H417R) in humans with familial advanced sleep phase accompanied by higher Beck Depression Inventor...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Zhang, Luoying, Hirano, Arisa, Hsu, Pei-Ken, Jones, Christopher R., Sakai, Noriaki, Okuro, Masashi, McMahon, Thomas, Yamazaki, Maya, Xu, Ying, Saigoh, Noriko, Saigoh, Kazumasa, Lin, Shu-Ting, Kaasik, Krista, Nishino, Seiji, Ptáček, Louis J., Fu, Ying-Hui
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2016
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801303/
https://ncbi.nlm.nih.gov/pubmed/26903630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600039113
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