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Direct observation of ultrafast large-scale dynamics of an enzyme under turnover conditions
The functional cycle of many proteins involves large-scale motions of domains and subunits. The relation between conformational dynamics and the chemical steps of enzymes remains under debate. Here we show that in the presence of substrates, domain motions of an enzyme can take place on the microsec...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5879700/ https://ncbi.nlm.nih.gov/pubmed/29531052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720448115 |
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