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Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine
Large protein machines are tightly regulated through allosteric communication channels. Here we demonstrate the involvement of ultrafast conformational dynamics in allosteric regulation of ClpB, a hexameric AAA+ machine that rescues aggregated proteins. Each subunit of ClpB contains a unique coiled-...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6440998/ https://ncbi.nlm.nih.gov/pubmed/30926805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09474-6 |
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