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Long-Range Charge Reorganization as an Allosteric Control Signal in Proteins
[Image: see text] A new mechanism of allostery in proteins, based on charge rather than structure, is reported. We demonstrate that dynamic redistribution of charge within a protein can control its function and affect its interaction with a binding partner. In particular, the association of an antib...
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| Publicado no: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2020
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7735699/ https://ncbi.nlm.nih.gov/pubmed/33211484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c10105 |
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