Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form

For cancer cells to survive and proliferate, they must escape normal immune destruction. One mechanism by which this is accomplished is through immune suppression effected by up-regulation of indoleamine 2,3-dioxygenase (IDO1), a heme enzyme that catalyzes the oxidation of tryptophan to N-formylkynu...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Nelp, Micah T., Kates, Patrick A., Hunt, John T., Newitt, John A., Balog, Aaron, Maley, Derrick, Zhu, Xiao, Abell, Lynn, Allentoff, Alban, Borzilleri, Robert, Lewis, Hal A., Lin, Zeyu, Seitz, Steven P., Yan, Chunhong, Groves, John T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2018
Gaiak:
Physical Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879690/
https://ncbi.nlm.nih.gov/pubmed/29531094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719190115
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