Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form

For cancer cells to survive and proliferate, they must escape normal immune destruction. One mechanism by which this is accomplished is through immune suppression effected by up-regulation of indoleamine 2,3-dioxygenase (IDO1), a heme enzyme that catalyzes the oxidation of tryptophan to N-formylkynu...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Nelp, Micah T., Kates, Patrick A., Hunt, John T., Newitt, John A., Balog, Aaron, Maley, Derrick, Zhu, Xiao, Abell, Lynn, Allentoff, Alban, Borzilleri, Robert, Lewis, Hal A., Lin, Zeyu, Seitz, Steven P., Yan, Chunhong, Groves, John T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2018
Konular:
Physical Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879690/
https://ncbi.nlm.nih.gov/pubmed/29531094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719190115
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