Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration

Inherited retinal degeneration (RD) is a devastating and currently untreatable neurodegenerative condition that leads to loss of photoreceptor cells and blindness. The vast genetic heterogeneity of RD, the lack of “druggable” targets, and the access-limiting blood–retinal barrier (BRB) present major...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Vighi, Eleonora, Trifunović, Dragana, Veiga-Crespo, Patricia, Rentsch, Andreas, Hoffmann, Dorit, Sahaboglu, Ayse, Strasser, Torsten, Kulkarni, Manoj, Bertolotti, Evelina, van den Heuvel, Angelique, Peters, Tobias, Reijerkerk, Arie, Euler, Thomas, Ueffing, Marius, Schwede, Frank, Genieser, Hans-Gottfried, Gaillard, Pieter, Marigo, Valeria, Ekström, Per, Paquet-Durand, François
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879685/
https://ncbi.nlm.nih.gov/pubmed/29531030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718792115
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