Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology

[Image: see text] Noninvasive methods to modulate G protein-coupled receptors (GPCRs) with temporal and spatial precision are in great demand. Photopharmacology uses photons to control in situ the biological properties of photoswitchable small-molecule ligands, which bodes well for chemical biologic...

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發表在:J Am Chem Soc
Main Authors: Hauwert, Niels J., Mocking, Tamara A. M., Da Costa Pereira, Daniel, Kooistra, Albert J., Wijnen, Lisa M., Vreeker, Gerda C. M., Verweij, Eléonore W. E., De Boer, Albertus H., Smit, Martine J., De Graaf, Chris, Vischer, Henry F., de Esch, Iwan J. P., Wijtmans, Maikel, Leurs, Rob
格式: Artigo
語言:Inglês
出版: American Chemical Society 2018
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879491/
https://ncbi.nlm.nih.gov/pubmed/29470065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b11422
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