Endolysosomal pathway activity protects cells from neurotoxic TDP-43

The accumulation of protein aggregates in neurons is a typical pathological hallmark of the motor neuron disease amyotrophic lateral sclerosis (ALS) and of frontotemporal dementia (FTD). In many cases, these aggregates are composed of the 43 kDa TAR DNA-binding protein (TDP 43). Using a yeast model...

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Publicat a:Microb Cell
Autors principals: Leibiger, Christine, Deisel, Jana, Aufschnaiter, Andreas, Ambros, Stefanie, Tereshchenko, Maria, Verheijen, Bert M., Büttner, Sabrina, Braun, Ralf J.
Format: Artigo
Idioma:Inglês
Publicat: Shared Science Publishers OG 2018
Matèries:
Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878689/
https://ncbi.nlm.nih.gov/pubmed/29611555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2018.04.627
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