Neurotoxic 43-kDa TAR DNA-binding Protein (TDP-43) Triggers Mitochondrion-dependent Programmed Cell Death in Yeast

Pathological neuronal inclusions of the 43-kDa TAR DNA-binding protein (TDP-43) are implicated in dementia and motor neuron disorders; however, the molecular mechanisms of the underlying cell loss remain poorly understood. Here we used a yeast model to elucidate cell death mechanisms upon expression...

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Detalhes bibliográficos
Main Authors: Braun, Ralf J., Sommer, Cornelia, Carmona-Gutierrez, Didac, Khoury, Chamel M., Ring, Julia, Büttner, Sabrina, Madeo, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103370/
https://ncbi.nlm.nih.gov/pubmed/21471218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.194852
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