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CASPASE-9 CARD:CORE DOMAIN INTERACTIONS REQUIRE A PROPERLY-FORMED ACTIVE SITE

Caspase-9 is a critical factor in the initiation of apoptosis, and as a result is tightly regulated by a number of mechanisms. Caspase-9 contains a Caspase Activation and Recruitment Domain (CARD), which enables caspase-9 to form a tight interaction with the apoptosome, a heptameric activating platf...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Huber, Kristen L., Serrano, Banyuhay P., Hardy, Jeanne A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878146/
https://ncbi.nlm.nih.gov/pubmed/29500231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170913
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