Synthesis and Biological Evaluation of Bile Acid Analogues Inhibitory to Clostridium difficile Spore Germination

Standard antibiotic-based strategies for the treatment of Clostridium difficile infections disrupt indigenous microbiota and commonly fail to eradicate bacterial spores, two key factors that allow recurrence of infection. As an alternative approach to controlling C. difficile infection, a series of...

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Gepubliceerd in:J Med Chem
Hoofdauteurs: Stoltz, Kristen L., Erickson, Raymond, Staley, Christopher, Weingarden, Alexa R., Romens, Erin, Steer, Clifford J., Khoruts, Alexander, Sadowsky, Michael J., Dosa, Peter I.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877410/
https://ncbi.nlm.nih.gov/pubmed/28402634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00295
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