Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes

We have redesigned probes for in situ proximity ligation assay (PLA), resulting in more efficient localized detection of target proteins. In situ PLA depends on recognition of target proteins by pairs of antibody-oligonucleotide conjugates (PLA probes), which jointly give rise to DNA circles that te...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Klaesson, Axel, Grannas, Karin, Ebai, Tonge, Heldin, Johan, Koos, Björn, Leino, Mattias, Raykova, Doroteya, Oelrich, Johan, Arngården, Linda, Söderberg, Ola, Landegren, Ulf
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5876389/
https://ncbi.nlm.nih.gov/pubmed/29599435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23582-1
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