Improved efficiency of in situ protein analysis by proximity ligation using UnFold probes

We have redesigned probes for in situ proximity ligation assay (PLA), resulting in more efficient localized detection of target proteins. In situ PLA depends on recognition of target proteins by pairs of antibody-oligonucleotide conjugates (PLA probes), which jointly give rise to DNA circles that te...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Klaesson, Axel, Grannas, Karin, Ebai, Tonge, Heldin, Johan, Koos, Björn, Leino, Mattias, Raykova, Doroteya, Oelrich, Johan, Arngården, Linda, Söderberg, Ola, Landegren, Ulf
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5876389/
https://ncbi.nlm.nih.gov/pubmed/29599435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23582-1
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