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Genome-scale signatures of gene interaction from compound screens predict clinical efficacy of targeted cancer therapies
Identifying reliable drug response biomarkers is a significant challenge in cancer research. We present CARE, a computational method focused on targeted therapies, to infer genome-wide transcriptomic signatures of drug efficacy from cell line compound screens. CARE outputs genome-scale scores to mea...
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| Publicado no: | Cell Syst |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5876130/ https://ncbi.nlm.nih.gov/pubmed/29428415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.01.009 |
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