Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR library

CRISPR/Cas9 screens have been widely adopted to analyse coding gene functions, but high throughput screening of non-coding elements using this method is more challenging, because indels caused by a single cut in non-coding regions are unlikely to produce a functional knockout. A high-throughput meth...

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Detaylı Bibliyografya
Yayımlandı:Nat Biotechnol
Asıl Yazarlar: Zhu, Shiyou, Li, Wei, Liu, Jingze, Chen, Chen-Hao, Liao, Qi, Xu, Ping, Xu, Han, Xiao, Tengfei, Cao, Zhongzheng, Peng, Jingyu, Yuan, Pengfei, Brown, Myles, Liu, Xiaole Shirley, Wei, Wensheng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592164/
https://ncbi.nlm.nih.gov/pubmed/27798563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3715
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