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Guide RNAs with embedded barcodes boost CRISPR-pooled screens
Abstract We report a new method using re-designed guide RNAs with internal barcodes (iBARs) embedded in their loop regions. Our iBAR approach outperforms the conventional method by producing screening results with much lower false-positive and false-negative rates especially with a high multiplicity...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2019-01-01
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| Colecção: | Genome Biology |
| Acesso em linha: | http://link.springer.com/article/10.1186/s13059-019-1628-0 |
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