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Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition

Extensive parenchymal and vascular Aβ deposits are pathological hallmarks of Alzheimer’s disease (AD). Besides classic full-length peptides, biochemical analyses of brain deposits have revealed high degree of Aβ heterogeneity likely resulting from the action of multiple proteolytic enzymes. In spite...

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Dettagli Bibliografici
Pubblicato in:Biochim Biophys Acta
Autori principali: Cabrera, Erwin, Mathews, Paul, Mezhericher, Emiliya, Beach, Thomas G., Deng, Jingjing, Neubert, Thomas A., Rostagno, Agueda, Ghiso, Jorge
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5875988/
https://ncbi.nlm.nih.gov/pubmed/28711595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2017.07.005
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